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CVE-2026-31964

HTSlib CRAM decoder has a NULL Pointer Dereference

Medium6.9EPSS 0.34%
Published
Updated
Reserved
Assigned by
GitHub_M

Description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Scores

CVSS scores of CVE-2026-31964, by who scored it
Scored byCVSSScoreVector
GitHub_MCNA (assigner)4.0Medium6.9CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:L/VA:L/SC:N/SI:N/SA:N
NVDNVD · Analyzed4.0Medium6.9CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:L/VA:L/SC:N/SI:N/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X
EPSS (exploitation in 30 days)
0.34% · top 72% of all CVEs (6 Nov 2026)
CISA SSVC
Exploitation: none · Automatable: yes · Technical impact: partial
Loading the EPSS history…

The list uses the assigner's score when there is one, then CISA's, then NVD's: Medium 6.9.

Weakness

Affected products

  • samtools · htslib

    • affected < 1.21.1
    • affected >= 1.22, < 1.22.2
    • affected = 1.23

References (2)

Sources

The same CVE in the primary databases and aggregators, to check against.

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Record last updated .